Doxepin is a tricyclic antidepressant (TCA) used to treat major depressive disorder, anxiety disorders, chronic hives, and for short-term help with trouble remaining asleep after going to bed (a form of insomnia).
Doxepin is a reuptake inhibitor of serotonin and norepinephrine, or a serotonin–norepinephrine reuptake inhibitor (SNRI), and has additional antiadrenergic, antihistamine, antiserotonergic, and anticholinergic activities.   It is specifically an antagonist of the histamine H 1 and H 2 receptors, the serotonin 5-HT 2A and 5-HT 2C receptors, the α 1 -adrenergic receptor, and the muscarinic acetylcholine receptors ( M 1 – M 5 ).  Similarly to other TCAs, doxepin is also a potent blocker of voltage-gated sodium channels, and this action is thought to be involved in both its lethality in overdose  and its effectiveness as an analgesic (including in the treatment of neuropathic pain,  as a migraine prophylactic,  and as a local anesthetic ).
Learn about Sinequan (Doxepin) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Anti-anxiety effect is apparent before the antidepressant effect. Optimal antidepressant effect may not be evident for two to three weeks.
Skin rash, edema, photosensitization, and pruritus have occasionally occurred.
Alcohol: It should be borne in mind that alcohol ingestion may increase the danger inherent in any intentional or unintentional SINEQUAN overdosage. This is especially important in patients who may use alcohol excessively.
NOTE: Some of the adverse reactions noted below have not been specifically reported with SINEQUAN use.
Doxepin is used to treat depression and anxiety. Doxepin is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed for mental balance. Doxepin is also available as a tablet to treat insomnia.
It may take several weeks or longer for you to feel the full effect of doxepin. Continue to take doxepin even if you feel well. Do not stop taking doxepin without talking to your doctor. Your doctor will probably want to decrease your dose gradually.
Doxepin may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule.
Find patient medical information for Doxepin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Get medical help right away if you have any very serious side effects, including: severe dizziness, fast/irregular heartbeat, fainting, seizures, eye pain /swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night).
Some products that may interact with this drug include: arbutamine, thyroid supplements, anticholinergic drugs (such as benztropine, belladonna alkaloids), central-acting drugs to treat high blood pressure (such as clonidine, guanabenz).
See also Warning section.
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Antidepressant medications are used to treat a variety of conditions, including depression and other mental/ mood disorders.
3 days ago Doxepin is a dibenzoxepin-derivative tricyclic antidepressant (TCA). Structurally similar to phenothiazines, TCAs contain a tricyclic ring system.
Equilibrium dialysis indicate a mean protein binding of 75.5% for doxepin and 76.0% for desmethyldoxepin.
* Oral: * - Indicated for the treatment of depression and/or anxiety. - Indicated for the treatment of depression and/or anxiety associated with different conditions, including alcoholism, organic disease and manic-depressive disorders. - Indicated for the treatment of insomnia characterized by difficulties with sleep maintenance.
Doxepin is widely distributed throughout the body tissues. The mean apparent volume of distribution following a single 6 mg oral dose of Silenor to healthy subjects was 11,930 L.
In a thorough QTc prolongation clinical study in healthy subjects, doxepin had no effect on QT intervals or other electrocardiographic parameters after multiple daily doses up to 50 mg.
Doxepin, a tricyclic antidepressant of the dibenzoxepin type, is used to treat depression and anxiety and, topically, pruritus associated with eczema.