Chlorpromazine (CPZ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia.
It is commonly used to decrease nausea in animals that are too young for other common anti-emetics. [ citation needed ] It is also sometimes used as a preanesthetic and muscle relaxant in cattle, swine, sheep, and goats. [ citation needed ].
Chlorpromazine has tentative benefit in animals infected with Naegleria fowleri. .
Chlorpromazine does also act as FIASMA (functional inhibitor of acid sphingomyelinase ). .
Brand names include Thorazine, Largactil, Hibernal, and Megaphen (sold by Bayer in West-Germany since July 1953  ).
Chlorpromazine largely replaced electroconvulsive therapy, hydrotherapy,  psychosurgery, and insulin shock therapy.
Chlorpromazine is a psychiatric medication that belongs to the class of drugs called phenothiazine antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.
Before using this medication, l your doctor or pharmacist your medical history, especially of: liver problems, kidney problems, heart problems (such as mitral valve insufficiency, abnormal heart rhythm), low blood pressure, blockage of the intestines, glaucoma, seizures, enlarged prostate, breathing problems (such as severe asthma, emphysema, lung infections), blood disorders (such as bone marrow depression, low red/white/ plaet blood cell counts), low levels of calcium in the blood, loss of too much body water ( dehydration ), breast cancer, brain disorder/tumor/injury, exposure to organophosphate insecticides, pheochromocytoma, drug/alcohol/ substance abuse, Parkinson's disease.
Take this medication regularly to get the most benefit from it.
Medscape - Indication-specific dosing for Thorazine (chlorpromazine), frequency-based adverse effects, comprehensive interactions, contraindications.
Safer alternatives exist. X: Do not use in pregnancy. Risks involved outweigh potential benefits.
12.5-25 mg IM 1-2 hours before surgery.
Depresses hypothalamic thermoregulatory mechanism; exposure to extreme temperatures may cause hypo- or hyperthermia.
Metabolites: 10-12 different compounds Half-life: 30 hr Excretion: Urine.
This drug is not approved for treatment of patients with dementia-related psychosis Hypersensitivity to phenothiazines.
NA: Information not available.
Direct IV injection is only for control of nausea and vomiting during surgery and for adjunctive treatment of tetanus.
Duration: 4-6 hr; extended release, 10-12 hr Protein bound: 92-97% Vd: 20 L/kg.
≥6 months: 50-100 mg/day PO/IM; 200 mg/day or more may be necessary for older hospitalized patients; for outpatients, may administer 0.55 mg/kg q4-6hr PRN.
Use caution in glaucoma, prostatic hypertrophy, stenosing peptic ulcer disease (PUD), history of NMS, Parkinson disease, hypocalcemia, renal or hepatic impairment, history of severe reaction to insulin or electroconvulsive therapy (ECT), history of seizures, asthma, respiratory tract infection, cardiovascular disease, myelosuppression.
IV infusion is only for adjunctive treatment of intractable hiccups in adults.
25-50 mg PO q6-8hr; if hiccups persist after 2-3 days of oral therapy, administer 25-50 mg IM q3-4hr; if symptoms persist, administer 25-50 mg by slow IV infusion with patient lying flat in bed; monitor BP.
25-50 mg PO q6-8hr.
Metabolized by hepatic P450 enzyme CYP2D6.
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May cause extrapyramidal symptoms, including akathisia, acute dystonic reactions, and pseudoparkinsonism, and tardive dyskinesia; risk of dystonia greater with increased doses.
PO: 30-75 mg/day divided q6-12hr initially; maintenance: usually 200 mg/day (up to 800 mg/day in some patients; some patients may require 1-2 g/day).
Anticholinergic antiparkinsonian agent may be needed to counter EPS.
Patients with dementia-related psychosis who are treated with antipsychotic drugs are at increased risk for death, as shown in short-term controlled trials; deaths in these trials appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature.
Lactation: Drug enters breast milk; not recommended (American Academy of Pediatrics states that this is "of concern").
No Results No Results.
≥6 months: 0.55 mg/kg PO/IM 1-2 hours before surgery No Results Extrapyramidal symptoms Common Less common Uncommon Rare.
5-50 mg IV as single dose tablet injectable solution.
Significant hypotension may occur, especially with parenteral administration; hypotension may be particularly severe in patients with pheochromocytoma or mitral insufficiency; in case of severe hypotension, treat with norepinephrine or phenylepinephrine, and do not use epinephrine or dopamine.
Drugs & Diseases chlorpromazine (Rx) Brand and Other Names: Thorazine Classes: Antipsychotics, Phenothiazine Share Print Feedback Close Facebook Twitter LinkedIn Google+ Sections chlorpromazine (Rx) Sections chlorpromazine Dosing & Uses Interactions Adverse Effects Warnings Pregnancy Pharmacology Administration Images Patient Handout Formulary Dosing & Uses Adult Pediatric Dosage Forms & Strengths tablet injectable solution.
Consumer information about the medication CHLORPROMAZINE - ORAL (Thorazine), includes side effects, drug interactions, recommended dosages, and.
This medication is not approved for the treatment of dementia -related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor. WARNING: There may be a slightly increased risk of serious, possibly fatal side effects (such as heart failure, fast/irregular heartbeat, pneumonia ) when this medication is used by older adults with dementia.
Generalized Anxiety Disorder (GAD) Slideshow.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Find a comprehensive guide to possible side effects including common and rare side effects when taking Thorazine (Chlorpromazine) for healthcare.
Skin Pigmentation — Rare instances of skin pigmentation have been observed in hospitalized mental patients, primarily females who have received the drug usually for 3 years or more in dosages ranging from 500 mg to 1500 mg daily. The pigmentary changes, restricted to exposed areas of the body, range from an almost imperceptible darkening of the skin to a slate gray color, sometimes with a violet hue. Histological examination reveals a pigment, chiefly in the dermis, which is probably a melanin-like complex.