Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation.
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This causes the myocardium to work more efficiently, with optimized hemodynamics and an improved ventricular function curve. Overall, the heart rate is decreased while blood pressure is increased, resulting in a net increase in stroke volume, leading to increased tissue perfusion.
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Digoxin: learn about side effects, dosage, special precautions, and more on MedlinePlus.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Digoxin helps control your condition but will not cure it. Continue to take digoxin even if you feel well.
Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in atrial fibrillation and in the management of congestive.
Digoxin inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium. The sodium calcium exchanger (NCX)in turn tries to extrude the sodium and in so doing, pumps in more calcium. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Digoxin also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.
Drug created on June 13, 2005 07:24 / Updated on September 15, 2018 18:06.
Wolfgang Voigtlander, Fritz Kaiser, Wolfgang Schaumann, Kurt Stach, "Preparation of C22-alkyl derivative of digoxin." U.S.
Find patient medical information for Digoxin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
This drug may make you dizzy or blur your vision. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.
Some products have ingredients that could worsen your heart failure. l your pharmacist what products you are using, and ask how to use them safely (especially cough -and-cold products, diet aids, or NSAIDs such as ibuprofen / naproxen ).
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
Digoxin answers are found in the Davis's Drug Guide powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
PO: (Infants –premature): Digitalizing dose– 20–30 mcg/kg given as 50% of the dose initially and one quarter of the initial dose in each of 2 subsequent doses at 6–12 hr intervals. Maintenance dose– 5–7.5 mcg/kg given daily in 2 divided doses.
Elixir (lime flavor): 0.05 mg/mL Cost: Generic: $42.10/60 mL Injection: 0.25 mg/mL.
Pediatric injection: 0.1 mg/mL.
All dosing must be evaluated by individual response. Maintenance doses are determined for digoxin by renal function. In general, doses required for atrial arrhythmias are higher than those for inotropic effect.