Topihealsen.biz

Phenytoin


Phenytoin

12.22.2018 by Brianna Backer
Phenytoin
Phenytoin

Phenytoin (PHT), sold under the brand name Dilantin among others, is an anti-seizure medication. It is useful for the prevention of tonic-clonic seizures and partial seizures, but not absence seizures. The intravenous form is used for status epilepticus that does not improve with benzodiazepines.

Phenytoin ( PHT ), sold under the brand name Dilantin among others, [1] is an anti-seizure medication. [2] It is useful for the prevention of tonic-clonic seizures and partial seizures, but not absence seizures. [2] The intravenous form is used for status epilepticus that does not improve with benzodiazepines.

Dilantin (Phenytoin) Side Effects, Interactions, Warning, Dosage

11.21.2018 by Jason Bawerman
Phenytoin
Dilantin (Phenytoin) Side Effects, Interactions, Warning, Dosage

DILANTIN (phenytoin sodium) injection, USP is a sterile solution of 50 mg phenytoin sodium per milliliter for intravenous or intramuscular administration.

The addition or withdrawal of these agents in patients on phenytoin therapy may require an adjustment of the phenytoin dose to achieve optimal clinical outcome.

After opening, any unused product should be discarded. For single-dose only.

Phenytoin is 100% bioavailable by the IV route. For this reason, serum phenytoin concentrations may increase modestly when IV phenytoin is substituted for oral phenytoin sodium therapy. When treatment with oral phenytoin is not possible, IV DILANTIN can be substituted for oral phenytoin at the same total daily dose.

Phenytoin (Dilantin, Phenytek) Side Effects, Dosages, Treatment

9.19.2018 by Jason Bawerman
Phenytoin
Phenytoin (Dilantin, Phenytek) Side Effects, Dosages, Treatment

Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug). It works by reducing the spread of.

What Are Warnings and Precautions for Phenytoin?

An increase in seizure frequency may occur during pregnancy; periodic measurement of plasma phenytoin concentrations may be valuable to make appropriate dosage adjustments; postpartum restoration of original dosage will probably be indicated.

Children under 6 years: Potential toxic dose, 20 mg/kg.

Therapeutic range : 10-20 mcg/ L (total) or 1-2 mcg/L free drug Immediate release Extended release Initial dosage.

Consider vitamin K supplementation for one month before birth.

Phenytoin has moderate interactions with at least 286 different drugs.

Brain Disorders Image Collection.

Risk of low blood pressure (hypotension) and irregular heartbeats (arrhythmias) with infusion rates that exceed 50 mg/minute in adults and 1-3 mg/kg/minute (or 50 mg/minute, whichever is slower) for pediatric patients.

High blood sugar ( hyperglycemia ), resulting from drug's inhibitory effect on insulin release reported; phenytoin may also raise serum glucose level in patients diabetes mellitus ; use caution.

The FDA has not suggested that clinicians stop prescribing any drugs on the watch list or that patients stop taking them; it has, however, advised that patients with questions about watch-list drugs discuss them with their clinician.

Metabolized by hepatic cytochrome P450 enzymes CYP2C9 and CYP2C19, and is particularly susceptible to inhibitory drug interactions because it is subject to saturable metabolism; if metabolism inhibited, may produce significant increases in circulating phenytoin concentrations and enhance the risk of drug toxicity.

Acute alcoholic intake may increase phenytoin serum levels, while chronic alcoholic use may decrease serum levels.

Phenytoin is secreted in human milk; developmental and health benefits of breastfeeding should be considered along with the mother 's clinical need for therapy and any potential adverse effects on breastfed infants from phenytoin or from the underlying maternal condition.

Rare side effects of phenytoin reported include:

Cardiovascular risk associated with rapid infusion rates:

See "What Are Side Effects Associated with Using Phenytoin?”

Increased risk of suicidal thoughts or behavior reported.

Decreased bone mineral density reported with chronic use.

Pharmacy Locater Tool Including 24 Hour, Pharmacies.

Dosage Forms and Strengths Capsule, immediate-release Capsule, extended-release Tablet, chewable Oral suspension Injectable solution Seizures Status epilepticus Anticonvulsant, Adult Tablet Suspension Extended release.

This document does not contain all possible interactions.

Phenytoin, Dilantin Drug Facts, Side Effects, and Dosing

8.18.2018 by Isaac Mercer
Phenytoin
Phenytoin, Dilantin Drug Facts, Side Effects, and Dosing

Phenytoin is an anti-seizure medication (anticonvulsant) used for preventing or treating generalized tonic-clonic (grand mal) seizures, complex partial seizures (psychomotor seizures), and seizures occurring during or after neurosurgery. It may be used alone or with phenobarbital or other anticonvulsants.

Seizures are divided into two categories: generalized and partial. Generalized seizures are produced by electrical impulses from.

Brain Disorders Image Collection.

Epilepsy Slideshow. Phenytoin is an anti- seizure medication ( anticonvulsant ) used for preventing or treating generalized tonic-clonic (grand mal) seizures, complex partial seizures (psychomotor seizures), and seizures occurring during or after neurosurgery. It may be used alone or with phenobarbital or other anticonvulsants.

The body.

Dilantin, Phenytek (phenytoin) dosing, indications, interactions

6.16.2018 by Brianna Backer
Phenytoin
Dilantin, Phenytek (phenytoin) dosing, indications, interactions

Medscape - Seizure-specific dosing for Dilantin, Phenytek (phenytoin), frequency-based adverse effects, comprehensive interactions, contraindications.

Use caution in cardiovascular disease, hypoalbuminemia, hepatic impairment, hypothyroidism, or seizures; because fraction of unbound phenytoin is increased in patients with renal or hepatic disease, or in those with hypoalbuminemia, the monitoring of phenytoin serum levels should be based on the unbound fraction in those patients.

Cardiovascular risk associated with rapid infusion rates Hypersensitivity Sinus bradycardia Sinoatrial block.

IV infusion not recommended by many due to poor solubility and risk of crystal formation; others state it is doable with right solvent and concentration.

Risk of gingival hyperplasia.

The recipient will receive more details and instructions to access this offer.

Antiepileptic drugs should not be abruptly discontinued because of the possibility of increased seizure frequency, including status epilepticus.

Sustained serum levels of phenytoin above optimal range may produce confusional states referred to as "delirium", "psychosis", or "encephalopathy", or rarely irreversible cerebellar dysfunction; accordingly, at the first sign of acute toxicity, plasma levels are recommended; dose reduction of phenytoin therapy is indicated if plasma levels are excessive; termination recommended if symptoms persist.

Adding plans allows you to:

May cause fetal harm when administered to a pregnant woman.

May render OCPs ineffective because of induction of hepatic metabolism.

Gingival hyperplasia (pediatric patients) Ataxia Paradoxical seizure Drug withdrawal seizure Diplopia Psychosis (high dose) Toxic amblyopia Encephalopathy AV conduction disorder Ventricular fibrillation Nausea Vomiting Constipation Diarrhea Megaloblastic (folate-deficiency) anemia Hypocalcemia Hepatotoxicity Hypertrichosis Lymphadenopathy Purple glove syndrome Rash.

Second and third degree A-V block Adams-Stokes syndrome.

The FDA has not suggested that clinicians stop prescribing any drugs on the watch list or that patients stop taking them; it has, however, advised that patients with questions about watch-list drugs discuss them with their clinician.

Allergic reactions in the form of rash or, rarely, more serious forms (drug reaction with eosinophilia and systemic symptoms, or DRESS) or anaphylaxis Purpuric rash Toxic epidermal necrolysis Bullous dermatosis.

Phenytoin is a potent inducer of hepatic drug-metabolizing enzymes.

Metabolized by hepatic P450 enzyme CYP2C9 Metabolites: Inactive Enzymes induced: CYP3A4.

Erratically absorbed when administered IM, so this route should be used as a last resort.

C: Use with caution if benefits outweigh risks.