Promethazine: learn about side effects, dosage, special precautions, and more on MedlinePlus.
Promethazine suppositories are for rectal use only. Do not try to swallow the suppositories or insert in any other part of your body.
If you are taking promethazine liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the medication or use a spoon made especially for measuring medication.
Duplication for commercial use must be authorized by ASHP. AHFS Patient Medication Information., 2018. The American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland.
Keep this medication in the carton or container it came in, tightly closed, and out of reach of children.
Promethazine is a first-generation antihistamine of the phenothiazine family. The drug has strong sedative and weak antipsychotic effects. It also reduces motion.
Promethazine is listed as one of the drugs of highest anticholinergic activity in a study of anticholinergenic burden, including long-term cognitive impairment. 
Another notable use of promethazine is as a local anesthetic, by blockade of sodium channels. 
Extremely rare side effects include:
In 2009, the US Supreme Court ruled on a product liability case involving promethazine. Diana Levine, a woman suffering from a migraine, was administered Wyeth 's Phenergan via IV push. The drug was injected improperly, resulting in gangrene and subsequent amputation of her right forearm below the elbow.
Each tablet, for oral administration, contains 25 mg or 50 mg of promethazine hydrochloride. Promethazine Hydrochloride Tablets USP, 50 mg also contain anhydrous lactose. The administration of promethazine HCl (promethazine hydrochloride) in 25-mg doses will control minor.
Each tablet, for oral administration, contains 25 mg or 50 mg of promethazine hydrochloride. In addition each tablet contains the following inactive ingredients: dibasic calcium phosphate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and stearic acid.
Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults. Promethazine hydrochloride tablets are contraindicated for children under 2 years of age.
Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine HCl (promethazine hydrochloride).
PHENERGAN (promethazine hydrochloride) Suppositories, USP. DESCRIPTION. Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with.
Active and prophylactic treatment of motion sickness.
The average effective dose of promethazine HCl for the active therapy of nausea and vomiting in children or adults is 25 mg. 12.5- to 25-mg doses may be repeated, as necessary, at 4- to 6-hour intervals.
Cardiovascular – Increased or decreased blood pressure, tachycardia, bradycardia, faintness.
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Anticholinergics – Concomitant use of other agents with anticholinergic properties should be undertaken with caution.
CNS Depressants – Phenergan (Promethazine HCl) Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl.
Promethazine oral tablet is a prescription drug used to treat several conditions. These include allergies, motion sickness, nausea and vomiting, anxiety before.
For people with certain bladder problems: If you have a blockage in your bladder, taking this drug may make it more difficult for you to urinate. This is because it narrows the tubes through which your urine flows.
All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on: Generic: Promethazine.
Most stomachaches aren't serious and the symptoms pass quickly. Generally, there's no need to look further than your kitchen for a solution.
The drug should not be taken during an acute asthma attack or if you have COPD.